"The 4400" tells the stories of 4,400 alien abductees after they are returned to earth. In the words of the executive producers, these are stories of people dealing with traumatic changes, driven by the mystery of what happened and why. Some of them have been affected in mysterious ways, and some will have certain abilities, both good and bad, so part of the drama will be watching them adjust to these changes within themselves.
　　The series kicks off with a ball of light sailing toward Earth, but rather than the expected catastrophic event, thousands of returned abductees are left with no memory of their otherworldly experiences. Each has been gone anywhere from a few months to several decades but hasn't aged a day.
　　在海滩变乱——4400人被将来天下的人带走又送返来，披露后一年，天下产生了巨大的变革。颠末一段告急的医疗观察后，Tom回到了国度技能救济中心，由于本领有限，被派做文书事变。他终极掩护了儿子，使其免受一个雷同的当局研究，并且也为有盼望重新过上正常的生存而冲动。在奇迹方面，他也渴望再次同Diana相助，重新回到这个范畴。Diana，在同连续串无能的搭档相助之后，终极找到毁掉公牍让Tom重回岗亭的步伐，在此期间，她还正式收养了Maia。
　　其间，Richard，Lily，和他们的孩子——一个六个月大，差别平常的孩子，仍旧住在阔别Jordan Collier的山间小屋里，过着粗茶淡饭的日子。Collier已经关掉了Arcadia Estates ，尚有他的住宅，为这4400人建起了遁迹所，同时预备开“4400人中心”，在这儿，其他人可以深入到这4400人当中，本身去掘客4400人（的机密）。Collier在打仗Lily的腹部之后，出现了有害的反响，Shawn治愈了他，之后他们就生长出密切的父子干系。Collier成了Shawn的监护人，并利用他医治4400人中心的紧张赞助人。
　　众人对4400人甚感好奇，于是关于他们的秘密本领的浮名到处传播，大众态度分为两种，一种是包涵他们，一种是畏惧他们。当4400人积极重新开始他们“被打断的生存”时，每小我私家都市在即将产生的变乱中扮演关键脚色…那些决定人类运气的变乱。